[Debezo]

This honorific is no longer used in spoken japanese. it's outdated. it's only used for addressee on an awards, a public correspondence, a bit of business/official letter or other very formal/public situation.
dono has about intermediate respect between sama and san in the present day.it was used toword norbles, loads, masters, meant person who lived in palace.
in anime, a character like a samurai or an archaic woman uses dono for san.
if anything, it's gravely saying than polite saying.