Fruits Basket made a cry, but that was just the manga. The anime was just cute, really.
I cried when the little cat dude in .HACK//SIGN died. And who CAN'T help but cry when watching Full Moon Wo Sagashite?! I watched the last episode over and over and over again and cried EVERY DANG TIME! Just THINKING about it makes me cry! Waaaaaaah!!!