Considering your arrival time, big luggage, and that you might be unaccustomed to public transportation facilities in Japan, I would recommend you to stay at the location which is accessible from Kansai International Airport (KIX), and from which you would easily be able to access your destination the next day (OSAKA UNIV. isn't it？).
I have just googled and found this,
Hotel A.P in front of Osaka Airport Osaka Japan -Discount Osaka Hotel Reservations-
Limusine Bus from KIX to Osaka International Airport (aka Itami Airport).
From Osaka International Airport to whichever campus of OSAKA UNIV. by OSAKA MONORAIL.
OSAKA MONORAIL CO.,LDT.
It is not cheap but reasonable for the location, I think. And you can make a reservation well in advance on net.