[Nyororin]

I have only heard 家内 used with the over 50 or so set. Everyone younger seems to introduce with 妻. I have also never heard 奥さん used even in a casual context. In my experience, 嫁 tends to be used most in casual situations.
Perhaps a generational difference?

For women, 主人 is #1, and 旦那 #2. Pretty much as Masaegu said - 旦那 is a bit more casual, but can still be used pretty much everywhere.